Microsponges Enriched Gel (MEGs): A Novel Strategy for Opthalmic Drug Delivery System Containing Ketotifen
نویسندگان
چکیده
Microsponge containing ketotifen drug with three different proportions of ethyl cellulose and drug were obtained successfully using quasi-emulsion solvent diffusion method. These formulations were studied for particle size and physical characterization. These microsponges enriched gel formulation were prepared by using 2 and 3 % w/w of SCMC and studied for viscosity, pH, gel strength, spreadability, bioadhesive force, drug content, in vitro release, HPLC and SEM analysis. The viscosity of microsponges enriched gel was found to be in the range 1299 to 1600 centipoises. The maximum gel strength and mucoadhesive force was found to be up to (8.12 sec) and (32.32 dynes/cm) respectively. The formulations exhibited spreadability (22.88 gm.cm/sec), The optimized formulations were able to release the drug up to 8 hours.
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